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One Remarkable Molecule: Filaggrin
Journal of Investigative Dermatology · 2011 · Vol. 132(3) · pp. 751–762
Sara Brown✉(University of Dundee)W.H. Irwin McLean(University of Dundee)
Dermatology and Skin DiseasesAllergic Rhinitis and SensitizationFood Allergy and Anaphylaxis ResearchFilaggrinIchthyosis vulgarisAtopic dermatitisDiseasePhenotypeDermatologyMedicinePathogenesisLamellar ichthyosisAllergy
MeSH terms
Filaggrin ProteinsDermatitis, AtopicHumansIntermediate Filament ProteinsRisk FactorsIchthyosis VulgarisGenetic Predisposition to Disease
Citations
509
FWCI
36.36
field-weighted impact
References
151
Percentile
100%
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References
Genes Encoding Structural Proteins of Epidermal Cornification and S100 Calcium-Binding Proteins Form a Gene Complex (“Epidermal Differentiation Complex”) on Human Chromosome 1q21
Journal of Investigative Dermatology · 1996 · 502 citations
Cytokine modulation of atopic dermatitis filaggrin skin expression
Journal of Allergy and Clinical Immunology · 2007 · 1,080 citations
Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis
Nature Genetics · 2006 · 2,920 citations
Filaggrin in the frontline: role in skin barrier function and disease
Journal of Cell Science · 2009 · 855 citations
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