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RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis

Nature Structural & Molecular Biology · 2012 · Vol. 19(9) · pp. 900–905
Francesca TuortoReinhard LiebersTanja MuschMatthias SchaeferSarah HofmannStefanie KellnerMichaela FryeMark HelmGeorg StoecklinFrank Lyko
RNA modifications and cancerEpigenetics and DNA MethylationCancer-related gene regulationTransfer RNAMethylationCytosineMethyltransferaseBiologyDNA methylationRNAProtein biosynthesisGeneticsMolecular biology

MeSH terms

AnimalsCell DifferentiationCells, CulturedCytosineDNA (Cytosine-5-)-MethyltransferasesFemaleMaleMethylationMethyltransferasesRNA, TransferProtein BiosynthesisGene DeletionMice, KnockoutRNA StabilityMice

Funding

  • Deutsches Krebsforschungszentrum
  • Deutsche Forschungsgemeinschaft
  • Institute of Genetics
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