review Open AccessTop 1% cited
Chk1 and Chk2 kinases in checkpoint control and cancer
Cancer Cell · 2003 · Vol. 3(5) · pp. 421–429
Jiří Bártek✉(Danish Cancer Society)Jiri Lukas(Danish Cancer Society)
DNA Repair MechanismsMicrotubule and mitosis dynamicsCancer-related Molecular PathwaysGenome instabilityG2-M DNA damage checkpointCell cycle checkpointCHEK1KinaseDNA damageBiologyCheckpoint Kinase 2Cancer researchDNA repair
MeSH terms
Checkpoint Kinase 1AnimalsBreast NeoplasmsCell CycleColonic NeoplasmsDNA RepairHumansModels, BiologicalMutationNeoplasmsProtein KinasesSignal TransductionTumor Suppressor Protein p53Protein Serine-Threonine KinasesProtein Structure, Tertiary
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References
DNA double-strand breaks: signaling, repair and the cancer connection
Nature Genetics · 2001 · 2,447 citations
ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1
Molecular and Cellular Biology · 2001 · 1,072 citations
ATM and related protein kinases: safeguarding genome integrity
Nature reviews. Cancer · 2003 · 2,539 citations
Cell cycle checkpoint signaling through the ATM and ATR kinases
Genes & Development · 2001 · 1,958 citations
Chk1 is an essential kinase that is regulated by Atr and required for the G<sub>2</sub>/M DNA damage checkpoint
Genes & Development · 2000 · 1,613 citations
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