reviewTop 1% cited

DNA double-strand breaks: signaling, repair and the cancer connection

Nature Genetics · 2001 · Vol. 27(3) · pp. 247–254

Kum Kum Khanna✉(QIMR Berghofer Medical Research Institute)Stephen P. Jackson(Wellcome Trust)

DNA Repair Mechanisms Effects of Radiation Exposure Carcinogens and Genotoxicity AssessmentBiologyDNA damageDNA repairCarcinogenesisGenome instabilityDNACell biologyGeneticsGene

MeSH terms

AnimalsCell CycleDNA DamageDNA RepairDNA-Binding ProteinsDNA, NeoplasmHumansNeoplasm ProteinsNeoplasmsRecombination, GeneticTranscription FactorsSignal TransductionTumor Suppressor Protein p53Protein Serine-Threonine KinasesCell Cycle Proteins

Citations

2,447

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43.40

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References

Chk1 is an essential kinase that is regulated by Atr and required for the G<sub>2</sub>/M DNA damage checkpoint

Genes & Development · 2000 · 1,613 citations

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