article Open AccessTop 10% cited
Epithelial Transport Of Drugs In Cell Culture. I: A Model For Studying The Passive Diffusion Of Drugs Over Intestinal Absorbtive (Caco-2) Cells
Journal of Pharmaceutical Sciences · 1990 · Vol. 79(6) · pp. 476–482
Per Artursson✉(Uppsala University)
Drug Transport and Resistance MechanismsPharmaceutical studies and practicesDrug Solubulity and Delivery SystemsCaco-2AtenololLipophilicityPassive transportChemistryIntestinal epitheliumCell cultureBiophysicsParacellular transportEpithelium
MeSH terms
HumansIntestinal AbsorptionAdrenergic beta-AntagonistsBiological TransportCells, CulturedChemistry, PhysicalDiffusionEpitheliumModels, BiologicalChemical Phenomena
Citations
833
FWCI
14.00
field-weighted impact
References
29
Percentile
99%
vs. same field & year
Citations per year
Cited by
Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
Biochemical and Biophysical Research Communications · 1991 · 1,852 citations
Effect of Chitosan on the Permeability of Monolayers of Intestinal Epithelial Cells (Caco-2)
Pharmaceutical Research · 1994 · 768 citations
Caco‐2 versus Caco‐2/HT29‐MTX Co‐cultured Cell Lines: Permeabilities Via Diffusion, Inside‐ and Outside‐Directed Carrier‐Mediated Transport
Journal of Pharmaceutical Sciences · 2000 · 464 citations
Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs
Biomaterials · 2004 · 1,432 citations
The Mechanism of Uptake of Biodegradable Microparticles in Caco-2 Cells Is Size Dependent
Pharmaceutical Research · 1997 · 853 citations
The influence of surface modification on the cytotoxicity of PAMAM dendrimers
International Journal of Pharmaceutics · 2003 · 715 citations
Caco-2 monolayers in experimental and theoretical predictions of drug transport1PII of original article: S0169-409X(96)00415-2. The article was originally published in Advanced Drug Delivery Reviews 22 (1996) 67–84.1
Advanced Drug Delivery Reviews · 2001 · 1,524 citations
MDCK (Madin-Darby Canine Kidney) Cells: A Tool for Membrane Permeability Screening
Journal of Pharmaceutical Sciences · 1999 · 960 citations
References
Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability
Gastroenterology · 1989 · 2,193 citations
One Hundred and Twenty-Seven Cultured Human Tumor Cell Lines Producing Tumors in Nude Mice23
JNCI Journal of the National Cancer Institute · 1977 · 1,581 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.