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Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound

Journal of Medicinal Chemistry · 1997 · Vol. 40(14) · pp. 2113–2116
Daekyu SunBrian ThompsonBrian E. CathersMiguel SalazarSean M. KerwinJohn O. TrentTerence C. JenkinsStephen NeidleLaurence H. Hurley

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTInhibition of Human Telomerase by a G-Quadruplex-Interactive CompoundDaekyu Sun, Brian Thompson, Brian E. Cathers, Miguel Salazar, Sean M. Kerwin, John O. Trent, Terence C. Jenkins, Stephen Neidle, and Laurence H. HurleyView Author Information Institute for Drug Development, 14960 Omicron Drive, San Antonio, Texas 78245-3217, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712-1074, and CRC Biomolecular Structure Unit, The Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom Cite this: J. Med. Chem. 1997, 40, 14, 2113–2116Publication Date (Web):July 4, 1997Publication History Received25 March 1997Published online4 July 1997Published inissue 1 July 1997https://pubs.acs.org/doi/10.1021/jm970199zhttps://doi.org/10.1021/jm970199zrapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views5835Altmetric-Citations687LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Chemical structure,G-Quadruplex,Genetics,Inhibition,Peptides and proteins Get e-Alerts

DNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryCitationLibrary scienceSocial mediaComputer scienceInformation retrievalWorld Wide Web

MeSH terms

AnthraquinonesBase SequenceDNAEnzyme InhibitorsHumansNucleic Acid ConformationNucleic Acid DenaturationOligodeoxyribonucleotidesMolecular StructureTelomerase
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