articleTop 1% cited
Oxidative stress with an activation of the renin–angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction
Journal of Hypertension · 2010 · Vol. 28(6) · pp. 1234–1242
Min-A Yu(Ewha Womans University)Laura Gabriela Sánchez‐Lozada(University of Colorado Denver)Richard J. Johnson(University of Colorado Denver)Duk‐Hee Kang✉(GTx (United States))
Abstract
Uric acid-induced aging and death of human endothelial cells are medicated by local activation of oxidative stress and the renin-angiotensin system, which provides a novel mechanism of uric acid-induced endothelial dysfunction. Therapies targeting uric acid maybe beneficial in cardiovascular disease.
Gout, Hyperuricemia, Uric AcidElectron Spin Resonance StudiesNitric Oxide and Endothelin EffectsEndothelial dysfunctionOxidative stressUric acidReactive oxygen speciesAngiotensin IIUmbilical veinEndocrinologyMedicineInternal medicineDichlorofluorescein
MeSH terms
Cells, CulturedEndothelium, VascularHumansRenin-Angiotensin SystemUric AcidPolymerase Chain ReactionCellular SenescenceApoptosisReactive Oxygen SpeciesOxidative StressCell Proliferation
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