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Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin–angiotensin system

Journal of Hypertension · 2008 · Vol. 26(2) · pp. 269–275

Dalila B. Corry(Olive View-UCLA Medical Center)Pirooz Eslami(University of California, Los Angeles)Kei Yamamoto(University of California, Los Angeles)M D Nyby✉(University of California, Los Angeles)Hirofumi Makino(VA Greater Los Angeles Healthcare System)Michael L. Tuck(University of California, Los Angeles)

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Abstract

These results demonstrate that uric acid stimulates proliferation, angiotensin II production, and oxidative stress in VSMC through tissue RAS. This suggests that uric acid causes cardiovascular disorders by stimulating the vascular RAS, and this stimulation may be mediated by the MAP kinase pathway.

Gout, Hyperuricemia, Uric Acid Alcohol Consumption and Health Effects Pharmacological Effects of Natural CompoundsLosartanUric acidVascular smooth muscleEndocrinologyInternal medicineCaptoprilOxidative stressAngiotensin IIMedicineRenin–angiotensin system

MeSH terms

Angiotensin IIAnimalsAortaMaleMuscle, Smooth, VascularRenin-Angiotensin SystemUric AcidRats, Sprague-DawleyOxidative StressCell Culture TechniquesGene Expression ProfilingMitogen-Activated Protein Kinase KinasesMuscle CellsCell ProliferationRats

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759

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12.56

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Oxidative stress with an activation of the renin–angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction