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T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma

American Journal of Respiratory and Critical Care Medicine · 2009 · Vol. 180(5) · pp. 388–395

Prescott G. Woodruff✉(University of California, San Francisco)Barmak ModrekDavid F. Choy(Biomarker Technologies (China))Guiquan Jia(Biomarker Technologies (China))Alexander R. AbbasAlmut Ellwanger(Pulmonary and Critical Care Associates)Joseph R. Arron(Biomarker Technologies (China))Laura L. Koth(Pulmonary and Critical Care Associates)John V. Fahy(University of California, San Francisco)

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Abstract

Asthma can be divided into at least two distinct molecular phenotypes defined by degree of Th2 inflammation. Th2 cytokines are likely to be a relevant therapeutic target in only a subset of patients with asthma. Furthermore, current models do not adequately explain non-Th2-driven asthma, which represents a significant proportion of patients and responds poorly to current therapies.

Asthma and respiratory diseases IL-33, ST2, and ILC Pathways Allergic Rhinitis and SensitizationMedicineAsthmaImmunologyInflammationEosinophiliaInterleukin 13AllergyCystic fibrosisAllergic inflammationImmunoglobulin E

MeSH terms

FluticasoneAdministration, InhalationAdultAndrostadienesAsthmaBronchiBronchodilator AgentsFemaleHumansInflammationMaleMucinsPhenotypePulmonary FibrosisBiomarkers