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Highly Efficient Generation of Human Hepatocyte–Like Cells From Induced Pluripotent Stem Cells

Hepatology · 2009 · Vol. 51(1) · pp. 297–305

Karim Si‐Tayeb(Medical College of Wisconsin)Fallon K. Noto(Medical College of Wisconsin)Masato Nagaoka(Medical College of Wisconsin)Jixuan Li(Medical College of Wisconsin)Michele A. Battle(Medical College of Wisconsin)Christine Duris(Medical College of Wisconsin)Paula E. North(Medical College of Wisconsin)Stephen Dalton(University of Georgia)Stephen A. Duncan✉(Medical College of Wisconsin)

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Abstract

We demonstrate that mouse iPS cells retain full potential for fetal liver development and describe a procedure that facilitates the efficient generation of highly differentiated human hepatocyte-like cells from iPS cells that display key liver functions and can integrate into the hepatic parenchyma in vivo.

Pluripotent Stem Cells Research CRISPR and Genetic Engineering Pancreatic function and diabetesInduced pluripotent stem cellHuman Induced Pluripotent Stem CellsStem cellCell biologyHepatocyteChemistryBiologyEmbryonic stem cellBiochemistryIn vitro