articleTop 1% cited
Placental 11β‐hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure
Clinical Endocrinology · 1997 · Vol. 46(2) · pp. 161–166
Rafn Benediktsson✉(Western General Hospital)Andrew A. Calder(MRC Centre for Reproductive Health)Christopher R.W. Edwards(Western General Hospital)Jonathan R. Seckl(Western General Hospital)
Abstract
We conclude that human placental 11 beta-HSD plays a crucial role in controlling glucocorticoid access to the fetus. Other enzymes are not significant contributors at physiologically relevant cortisol concentrations.
Birth, Development, and HealthHormonal Regulation and HypertensionPregnancy and preeclampsia studiesCortisoneInternal medicineEndocrinologyGlucocorticoidFetusDehydrogenase11β-hydroxysteroid dehydrogenase type 1EnzymeBiologyHydrocortisone
MeSH terms
Administration, TopicalAnti-Inflammatory AgentsCortisoneFemaleGlycyrrhetinic AcidHumansHydrocortisoneHydroxysteroid DehydrogenasesOrgan Culture TechniquesPerfusionPlacenta11-beta-Hydroxysteroid Dehydrogenases
Citations
527
FWCI
16.21
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0
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99%
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Placental 11β‐hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure
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