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Mosaicism in Human Skin
Archives of Dermatology · 1993 · Vol. 129(11) · pp. 1460–1460
Rudolf Happle✉(Philipps University of Marburg)
Abstract
The concept of cutaneous mosaicism is important for gene mapping because here we have the opportunity to study two populations of cells differing only with regard to the mutation causing mosaicism. Future research will probably show that a specific genetic anomaly, when present as a mosaic, always produces the same type of cutaneous pattern.
Genetic and rare skin diseases.Cancer and Skin LesionsHedgehog Signaling Pathway StudiesBirthmarkLoss of heterozygosityGeneticsBiologyPhenotypeGermline mosaicismAlleleMutationOMIM : Online Mendelian Inheritance in ManGene
MeSH terms
AnimalsCloning, MolecularDosage Compensation, GeneticFemaleGenes, DominantHeterozygoteHumansKaryotypingGenetic LinkageMaleModels, BiologicalMosaicismMutationPhenotypeSkin
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References
Lethal genes surviving by mosaicism: A possible explanation for sporadic birth defects involving the skin
Journal of the American Academy of Dermatology · 1987 · 554 citations
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Mosaicism in Human Skin
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