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Characteristics and Concordance of Autism Spectrum Disorders Among 277 Twin Pairs

Archives of Pediatrics and Adolescent Medicine · 2009 · Vol. 163(10) · pp. 907–907

Rebecca E. Rosenberg✉(Kennedy Krieger Institute)Kiely Law(Kennedy Krieger Institute)Gayane Yenokyan(Johns Hopkins University)John McGready(Johns Hopkins University)Walter E. Kaufmann(Cancer Research And Biostatistics)Paul A. Law(Johns Hopkins University)

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Abstract

Our data support greater ASD concordance in MZ vs DZ twins. Overall higher functioning, psychiatric comorbidity, and Asperger syndrome concordance among affected MZ vs DZ twins may also suggest differential heritability for different ASDs. For families in which one MZ twin is diagnosed with ASD, the second twin is unlikely to receive an ASD diagnosis after 12 months. In addition, Internet parent report of ASD status is valid.

Autism Spectrum Disorder Research Genetics and Neurodevelopmental Disorders Child Development and Digital TechnologyZygosityConcordanceAutismMonozygotic twinAutism spectrum disorderTwin studyPsychologyAsperger syndromeSiblingHeritability

MeSH terms

Autistic DisorderChildChild Development Disorders, PervasiveCross-Sectional StudiesDiseases in TwinsFemaleHumansMaleTwins, DizygoticTwins, MonozygoticUnited StatesComorbiditySex DistributionAsperger Syndrome