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From Revolution to Evolution: The Glutamate Hypothesis of Schizophrenia and its Implication for Treatment
Neuropsychopharmacology · 2011 · Vol. 37(1) · pp. 4–15
Bita Moghaddam✉(University of Pittsburgh)Daniel C. Javitt(Nathan Kline Institute for Psychiatric Research)
Neuroscience and Neuropharmacology ResearchReceptor Mechanisms and SignalingNeurotransmitter Receptor Influence on BehaviorNeuroscienceGlutamate receptorNMDA receptorMetabotropic glutamate receptorSchizophrenia (object-oriented programming)GlutamatergicPsychologyMetabotropic glutamate receptor 5NeurotransmissionPrefrontal cortex
MeSH terms
HumansPsychotropic DrugsSchizophreniaReceptors, N-Methyl-D-AspartateNeurotransmitter AgentsGlutamic Acid
Funding
- National Institute of Mental Health
Citations
1,024
FWCI
21.41
field-weighted impact
References
116
Percentile
100%
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Citations per year
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References
Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex
Journal of Neuroscience · 1997 · 1,794 citations
Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans
Archives of General Psychiatry · 1994 · 3,315 citations
Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia
Neuroscience Letters · 1980 · 697 citations
The NIMH-MATRICS Consensus Statement on Negative Symptoms
Schizophrenia Bulletin · 2006 · 1,280 citations
Recent advances in the phencyclidine model of schizophrenia
American Journal of Psychiatry · 1991 · 2,911 citations
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