reviewTop 1% cited
Recent advances in the phencyclidine model of schizophrenia
American Journal of Psychiatry · 1991 · Vol. 148(10) · pp. 1301–1308
Daniel C. Javitt✉(Albert Einstein College of Medicine)Stephen R. Zukin
Abstract
These findings suggest that endogenous dysfunction of NMDA receptor-mediated neurotransmission might contribute to the pathogenesis of schizophrenia. The relative implications of the PCP and amphetamine models of schizophrenia are discussed in relationship to the diagnosis and etiology of schizophrenia.
Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorReceptor Mechanisms and SignalingPhencyclidinePsychotomimeticPsychosisNMDA receptorHallucinogenSchizophrenia (object-oriented programming)AmphetamineNeurosciencePharmacologyMescaline
MeSH terms
AnimalsDose-Response Relationship, DrugHumansMemoryPaired-Associate LearningPhencyclidinePhencyclidine AbuseSchizophreniaSchizophrenic PsychologyReceptors, N-Methyl-D-AspartateReceptors, PhencyclidineReceptors, NeurotransmitterMice
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2,911
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91
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References
Dementia Praecox or the Group of Schizophrenias
Journal of the American Medical Association · 1951 · 4,407 citations
Provocative tests with psychostimulant drugs in schizophrenia
Psychopharmacology · 1987 · 537 citations
Negative v Positive Schizophrenia
Archives of General Psychiatry · 1982 · 2,011 citations
The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia
Schizophrenia Bulletin · 1987 · 21,169 citations
ABNORMALITIES OF CEREBRAL BLOOD FLOW DISTRIBUTION IN PATIENTS WITH CHRONIC SCHIZOPHRENIA
Acta Psychiatrica Scandinavica · 1974 · 667 citations
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