articleTop 1% cited
A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses
Breast Cancer Research and Treatment · 2008 · Vol. 112(3) · pp. 533–543
David Cameron✉(University of Leeds)Michelle Casey(GlaxoSmithKline (United States))Michael F. Press(University of Southern California)Deborah Lindquist(Texas Oncology)Tadeusz Pieńkowski(Centrum Onkologii)C. Gilles Romieu(CEA Valduc)Stephen Chan(Nottingham University Hospitals NHS Trust)Agnieszka Jagiełło-Gruszfeld(University of Computer Sciences and Economics in Olsztyn)Bella Kaufman(Sheba Medical Center)John Crown(Cancer Trials Ireland)Arlene Chan(Mount Medical Centre)Mario Campone(Centre Hospitalier René-Dubos)Patrice Viens(Institut Paoli-Calmettes)Neville Davidson(Broomfield Hospital)Vera Gorbounova(Russian Cancer Research Center NN Blokhin)Johannes Isaac Raats(Cape Town Science Centre)Dimosthenis Skarlos(Henry Dunant Hospital)B. Newstat(GlaxoSmithKline (United States))Debasish Roychowdhury(GlaxoSmithKline (United States))Paolo Paoletti(GlaxoSmithKline (United States))Cristina Oliva(GlaxoSmithKline (United States))Stephen C. Rubin(GlaxoSmithKline (United States))Steven Stein(GlaxoSmithKline (United States))Charles E. Geyer(Allegheny General Hospital)
HER2/EGFR in Cancer ResearchCancer Treatment and PharmacologyPeptidase Inhibition and AnalysisLapatinibCapecitabineTrastuzumabMedicineInternal medicineOncologyTaxaneBreast cancerMetastatic breast cancerHazard ratio
MeSH terms
TrastuzumabCapecitabineLapatinibAdultAgedAged, 80 and overAntibodies, MonoclonalAntineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsDeoxycytidineFemaleFluorouracilHumansMiddle AgedNeoplasm Metastasis
Funding
- GlaxoSmithKline
Citations
802
FWCI
40.77
field-weighted impact
References
20
Percentile
100%
vs. same field & year
Citations per year
References
Efficacy and Safety of Trastuzumab as a Single Agent in First-Line Treatment of HER2-Overexpressing Metastatic Breast Cancer
Journal of Clinical Oncology · 2002 · 2,949 citations
New Guidelines to Evaluate the Response to Treatment in Solid Tumors
JNCI Journal of the National Cancer Institute · 2000 · 15,689 citations
Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/<i>neu</i>Oncogene
Science · 1987 · 11,680 citations
Multinational Study of the Efficacy and Safety of Humanized Anti-HER2 Monoclonal Antibody in Women Who Have HER2-Overexpressing Metastatic Breast Cancer That Has Progressed After Chemotherapy for Metastatic Disease
Journal of Clinical Oncology · 1999 · 2,788 citations
Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2
New England Journal of Medicine · 2001 · 11,439 citations
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