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Fate Maps of Neural Crest and Mesoderm in the Mammalian Eye

Investigative Ophthalmology & Visual Science · 2005 · Vol. 46(11) · pp. 4200–4200

Philip J. Gage✉William RhoadesSandra K. Prucka(University of Michigan–Ann Arbor)Tord Hjalt(Lund University)

Abstract

The data provide essential new information toward understanding the complex interactions required for normal development and function of the mammalian eye. The results also underscore the importance of confirming neural crest and mesoderm fates in a model mammalian system. The complementary systems used in this study should be useful for studying the respective cell fates in other organ systems.

Developmental Biology and Gene Regulation Hedgehog Signaling Pathway Studies Corneal Surgery and TreatmentsMesodermNeural crestBiologyMesenchymeParaxial mesodermEye developmentFGF and mesoderm formationFate mappingGeneticsCell biology

MeSH terms

Homeobox Protein PITX2AnimalsCell DifferentiationEyeFemaleMaleMesodermMice, TransgenicMorphogenesisNeural CrestNuclear ProteinsOculomotor MusclesPregnancyTranscription FactorsBiomarkers