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Relationship between RPE and Choriocapillaris in Age-Related Macular Degeneration

Investigative Ophthalmology & Visual Science · 2009 · Vol. 50(10) · pp. 4982–4982

D. Scott McLeod✉(Johns Hopkins Hospital)Rhonda Grebe(Johns Hopkins Hospital)Imran Ahmed Bhutto(Johns Hopkins Hospital)Carol Merges(Johns Hopkins Hospital)Takayuki Baba(Johns Hopkins Hospital)Gerard A. Lutty(Johns Hopkins Hospital)

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Abstract

The primary insult in GA appears to be at the level of the RPE, and there is an intimate relationship between retinal pigment epithelial atrophy and secondary CC degeneration. CC degeneration occurs in the presence of viable RPE in wet AMD. The RPE in regions of vascular dropout are presumably hypoxic, which may result in an increase in VEGF production by the RPE and stimulation of CNV.

Retinal Imaging and Analysis Retinal Diseases and Treatments Glaucoma and retinal disordersMacular degenerationChoroidal neovascularizationRetinal pigment epitheliumRetinalOphthalmologyAtrophyChoroidRetinaAge-related maculopathyMaculopathy

MeSH terms

AgedAged, 80 and overAlkaline PhosphataseAtrophyCapillariesChoroidFemaleHumansImmunoenzyme TechniquesMacular DegenerationMaleBruch MembraneChoroidal NeovascularizationRetinal Pigment Epithelium

Citations

555

FWCI

12.39

field-weighted impact

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Cited by

Choriocapillaris Vascular Dropout Related to Density of Drusen in Human Eyes with Early Age-Related Macular Degeneration