articleTop 1% cited
Choriocapillaris Vascular Dropout Related to Density of Drusen in Human Eyes with Early Age-Related Macular Degeneration
Investigative Ophthalmology & Visual Science · 2011 · Vol. 52(3) · pp. 1606–1606
Robert F. Mullins✉Micaela N. JohnsonElizabeth A. FaidleyJessica M. SkeieJian Huang(University of Iowa)
Abstract
These findings support the concept that microvascular changes are related to the pathogenesis of AMD and suggest that vascular endothelial cell loss occurs in association with sub-RPE deposit formation. Whether microvascular events are a cause or consequence of drusen or other deposit formation remains to be determined.
Retinal Diseases and TreatmentsRetinal Imaging and AnalysisGlaucoma and retinal disordersDrusenMacular degenerationRetinalOphthalmologyRetinal pigment epitheliumMedicineAnatomyPathology
MeSH terms
AgedAged, 80 and overCapillariesChoroidEndothelium, VascularFemaleHumansLeukocytesMacular DegenerationMaleMiddle AgedTissue DonorsRetinal DrusenLeukocyte Common AntigensChoroidal Neovascularization
Funding
- Foundation Fighting Blindness
- Macula Vision Research Foundation
Citations
379
FWCI
15.38
field-weighted impact
References
64
Percentile
99%
vs. same field & year
Citations per year
References
Drusen associated with aging and age‐related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease
The FASEB Journal · 2000 · 930 citations
Ageing and degeneration in the macular region: a clinico-pathological study.
British Journal of Ophthalmology · 1976 · 885 citations
Relationship between RPE and Choriocapillaris in Age-Related Macular Degeneration
Investigative Ophthalmology & Visual Science · 2009 · 555 citations
A role for local inflammation in the formation of drusen in the aging eye
American Journal of Ophthalmology · 2002 · 1,089 citations
Current Concepts in the Pathogenesis of Age-Related Macular Degeneration
Archives of Ophthalmology · 2004 · 1,001 citations
Drusen and Disciform Macular Detachment and Degeneration
Archives of Ophthalmology · 1973 · 591 citations
A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss
Archives of Ophthalmology · 2001 · 3,223 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.
