articleTop 10% cited

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901

Bioorganic & Medicinal Chemistry Letters · 2008 · Vol. 18(24) · pp. 6501–6504

Stephen D. Barrett(Pfizer (United States))Alexander J. Bridges(Pfizer (United States))David T. Dudley(Pfizer (United States))Alan R. Saltiel(Pfizer (United States))James H. Fergus(Pfizer (United States))Cathlin Flamme(Pfizer (United States))Amy M. Delaney(Pfizer (United States))Michael D. Kaufman(Pfizer (United States))S Lepage(Pfizer (United States))Wilbur R. Leopold(Pfizer (United States))Sally Przybranowski(Pfizer (United States))Judith S. Sebolt–Leopold(Pfizer (United States))Keri Van Becelaere(Pfizer (United States))Annette M. Doherty(Pfizer (United States))Robert M. Kennedy(Pfizer (United States))Dan Marston(Pfizer (United States))W. Allen Howard(Pfizer (United States))Yvonne Smith(Pfizer (United States))Joseph S. Warmus✉(Pfizer (United States))Haile Tecle(Pfizer (United States))

View via DOI Publisher page

Melanoma and MAPK Pathways PI3K/AKT/mTOR signaling in cancer Protein Tyrosine PhosphatasesBenzamideChemistryDiphenylaminePotencyIn vivoSolubilityPharmacologyChemical synthesisStereochemistryMEK inhibitor

MeSH terms

AnimalsBenzamidesBenzoatesChemistry, PharmaceuticalDiphenylamineEnzyme InhibitorsHydroxamic AcidsNeoplasm TransplantationSolubilityDrug DesignInhibitory Concentration 50Cell Line, TumorMAP Kinase Kinase Kinase 1Miceortho-Aminobenzoates

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