reviewTop 1% cited
A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin
Biochemical Pharmacology · 1999 · Vol. 57(7) · pp. 727–741
DavidA Gewirtz✉(Virginia Commonwealth University Medical Center)
Chemotherapy-induced cardiotoxicity and mitigationCancer Treatment and PharmacologyCancer therapeutics and mechanismsDaunorubicinAnthracyclineDoxorubicinPharmacologyChemistryTopoisomeraseCardiotoxicityDNADrugMechanism of action
MeSH terms
AnimalsAntibiotics, AntineoplasticDaunorubicinDNA DamageDNA, NeoplasmDoxorubicinFree RadicalsGlutathioneHeartHumansNeoplasmsLipid PeroxidationApoptosis
Citations
2,219
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References
Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.
The EMBO Journal · 1993 · 1,139 citations
Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells.
Molecular Pharmacology · 1994 · 440 citations
PCNA: structure, functions and interactions
Oncogene · 1997 · 945 citations
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