article Open AccessTop 1% cited
α-Synuclein Promotes Mitochondrial Deficit and Oxidative Stress
American Journal Of Pathology · 2000 · Vol. 157(2) · pp. 401–410
Leigh J. Hsu(University of California, San Diego)Yutaka Sagara(University of California, San Diego)Armando Arroyo(University of California, San Diego)Edward Rockenstein(Institut de Médecine de la Reproduction)Abbyann Sisk(Institute of Reproductive Medicine)Margaret Mallory(Reproductive Science Center)Jeff Wong(University of California, San Diego)Takato Takenouchi(Institut de Médecine de la Reproduction)Makoto Hashimoto(University of California, San Diego)Eliezer Masliah✉(Institut de Médecine de la Reproduction)
Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatmentsNerve injury and regenerationOxidative stressNeurodegenerationMitochondrionEndocrinologyInternal medicineBiologyCell biologyMedicineDisease
MeSH terms
AnimalsGlutathioneGonadotropin-Releasing HormoneMicroscopy, ElectronMitochondriaNerve Tissue ProteinsRNA, MessengerTumor Cells, CulturedGene Expression Regulation, NeoplasticOxidative StressMiceSynucleinsalpha-Synuclein
Funding
- National Institutes of Health
Citations
708
FWCI
19.90
field-weighted impact
References
57
Percentile
100%
vs. same field & year
Citations per year
Cited by
Aggregated α‐synuclein activates microglia: a process leading to disease progression in Parkinson's disease
The FASEB Journal · 2005 · 1,274 citations
MOLECULAR PATHOPHYSIOLOGY OF PARKINSON'S DISEASE
Annual Review of Neuroscience · 2005 · 1,280 citations
Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics
Journal of Clinical Medicine · 2020 · 242 citations
Subcutaneous Rotenone Exposure Causes Highly Selective Dopaminergic Degeneration and α-Synuclein Aggregation
Experimental Neurology · 2002 · 707 citations
Mitochondria take center stage in aging and neurodegeneration
Annals of Neurology · 2005 · 949 citations
References
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Journal of Biological Chemistry · 1951 · 317,666 citations
Identification of two distinct synucleins from human brain
FEBS Letters · 1994 · 1,064 citations
Oxidative stress induces amyloid-like aggregate formation of NACP/α-synuclein in vitro
Neuroreport · 1999 · 424 citations
AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease
Nature Genetics · 1998 · 3,865 citations
Abnormalities of the electron transport chain in idiopathic parkinson's disease
Annals of Neurology · 1989 · 1,067 citations
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
Cell · 1996 · 5,154 citations
Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
Science · 1997 · 8,181 citations
Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal
Journal of Neuroscience · 1988 · 1,611 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.