reviewTop 1% cited

Insulin, insulin-degrading enzyme and amyloid-β peptide in Alzheimer's disease: review and hypothesis

Neurobiology of Aging · 2005 · Vol. 27(2) · pp. 190–198

Wei Qiao Qiu✉(Tufts Medical Center)Marshal F. Folstein(Tufts University)

Alzheimer's disease research and treatments Dementia and Cognitive Impairment Research Neurological Disorders and TreatmentsInsulin-degrading enzymeInsulinAmylinEndocrinologyInternal medicineType 2 diabetesDiabetes mellitusApolipoprotein EAlzheimer's diseaseAmyloid (mycology)

MeSH terms

Alzheimer DiseaseAnimalsApolipoproteins EDiabetes Mellitus, Type 2HumansHyperinsulinismInsulinInsulysinModels, BiologicalRiskAmyloid beta-PeptidesApolipoprotein E4

Funding

Deutsches Krebsforschungszentrum
National Institute on Aging

Citations

528

FWCI

10.68

field-weighted impact

References

Percentile

99%

vs. same field & year

Citations per year

Cited by

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

Nature reviews. Neuroscience · 2011 · 2,852 citations

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

Neurobiology of Aging · 2008 · 759 citations

References

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Proceedings of the National Academy of Sciences · 1993 · 4,266 citations

Diabetes Mellitus and Risk of Alzheimer Disease and Decline in Cognitive Function

Archives of Neurology · 2004 · 1,256 citations

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

Biochemical and Biophysical Research Communications · 1984 · 5,345 citations

Association of diabetes mellitus and dementia: The Rotterdam Study

Diabetologia · 1996 · 674 citations

Diabetes mellitus and the risk of dementia

Neurology · 1999 · 2,113 citations

Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies

Diabetes · 2002 · 1,199 citations

Increased Risk of Type 2 Diabetes in Alzheimer Disease

Diabetes · 2004 · 948 citations

Citation Network

How this paper connects to the literature. Drag to explore, click any node to open that paper.