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Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

Neurobiology of Aging · 2008 · Vol. 31(2) · pp. 224–243
Aileen M. MoloneyRebecca J. GriffinSuzanne TimmonsRosemary O’ConnorRivka RavidCora O’Neill
Growth Hormone and Insulin-like Growth FactorsMitochondrial Function and PathologyPituitary Gland Disorders and TreatmentsInsulin receptorEndocrinologyInternal medicineIRS1ReceptorBiologyAlzheimer's diseaseNeurofibrillary tangleSignal transducing adaptor proteinGrowth factor

MeSH terms

AgedAged, 80 and overAlzheimer DiseaseAnimalsAstrocytesFemaleHumansMaleMice, TransgenicMiddle AgedNeuronsReceptor, InsulinTemporal LobeSignal TransductionNeurofibrillary Tangles

Funding

  • Health Research Board
  • Higher Education Authority
  • Science Foundation Ireland
Citations
759
FWCI
9.17
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65
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