articleTop 1% cited
Copper‐Catalyzed Asymmetric Allylic Alkylation
European Journal of Organic Chemistry · 2008 · Vol. 2008(22) · pp. 3765–3780
Caroline A. Falciola✉(University of Geneva)Alexandre Alexakis(University of Geneva)
Abstract
Abstract Over the past decade, much effort has been put on designing efficient chiral ligands and screening of the different parameters that govern the main challenges of asymmetric S N 2′ reactions, namely chemo‐, regio‐ and enantioselectivity. This review traces the evolution of the methodologies for creating stereogenic centers through asymmetric copper‐catalyzed allylic alkylation with the use of different organometallic reagents and their subsequent applications. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Asymmetric Synthesis and CatalysisSynthetic Organic Chemistry MethodsSynthesis and Catalytic ReactionsStereocenterChemistryTsuji–Trost reactionReagentAllylic rearrangementAlkylationEnantioselective synthesisCopperCatalysisCombinatorial chemistry
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References
Asymmetric Allylic Alkylation, an Enabling Methodology
The Journal of Organic Chemistry · 2004 · 527 citations
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