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An Expanded Evaluation of the Relationship of Four Alleles to the Level of Response to Alcohol and the Alcoholism Risk

Alcoholism Clinical and Experimental Research · 2005 · Vol. 29(1) · pp. 8–16

Xian‐Zhang Hu(National Institute on Alcohol Abuse and Alcoholism)Gábor Oroszi(National Institutes of Health)Jeffrey Chun(National Institutes of Health)Tom L. Smith(National Institute on Alcohol Abuse and Alcoholism)David Goldman(National Institute on Alcohol Abuse and Alcoholism)Marc A. Schuckit✉(National Institutes of Health)

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Abstract

This report strengthens the support for a relationship between the HTTLPR L and GABAAalpha6 Ser385 alleles to low alcohol LR and to alcoholism in a prospectively studied cohort evaluated for LR in young adulthood and before the onset of alcohol dependence.

Neurotransmitter Receptor Influence on Behavior Biochemical Analysis and Sensing Techniques Nicotinic Acetylcholine Receptors StudySerotonin transporterAlleleSpouseAlcohol dependenceAlcohol abuseAlcohol5-HTTLPRAlcohol use disorderGenotypePsychology

MeSH terms

AdultAlcohol DrinkingAlcoholismAllelesFollow-Up StudiesHumansMaleMembrane GlycoproteinsNerve Tissue ProteinsProspective StudiesReceptors, GABA-ARisk FactorsMembrane Transport ProteinsSerotonin Plasma Membrane Transport Proteins

Citations

488

FWCI

12.48

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102

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100%

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