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Childhood adversity, adult stressful life events, and risk of past-year psychiatric disorder: a test of the stress sensitization hypothesis in a population-based sample of adults

Psychological Medicine · 2009 · Vol. 40(10) · pp. 1647–1658
Katie A. McLaughlinKerith J. ConronKarestan C. KoenenStephen E. Gilman

Abstract

CA is associated with increased vulnerability to the deleterious mental health effects of adult stressors in both men and women. High levels of CA may represent a general diathesis for multiple types of psychopathology that persists throughout the life course.

Child Abuse and TraumaChild and Adolescent Psychosocial and Emotional DevelopmentMigration, Health and TraumaStressorAnxietyPsychopathologyDepression (economics)PsychiatryPsychologyClinical psychologyMental healthPopulationSensitization

MeSH terms

AdultAgedAnxiety DisordersDepressive Disorder, MajorMajor Depressive DisorderFemaleHumansLife Change EventsMaleMiddle AgedModels, PsychologicalPsychotic DisordersRisk FactorsStress Disorders, Post-TraumaticStress, Psychological

Funding

  • Robert Wood Johnson Foundation
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Childhood adversity, adult stressful life events, and risk of past-year psychiatric disorder: a test of the stress sensitization hypothesis in a population-based sample of adults · Scinovex