articleTop 1% cited

The cellular thermal shift assay for evaluating drug target interactions in cells

Nature Protocols · 2014 · Vol. 9(9) · pp. 2100–2122

Rozbeh Jafari✉(Karolinska Institutet)Helena AlmqvistHanna AxelssonMarina Ignatushchenko(Karolinska Institutet)Thomas LundbäckP. Nordlund(Karolinska Institutet)Daniel Martinez Molina(Karolinska Institutet)

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Computational Drug Discovery Methods Protein Structure and Dynamics Monoclonal and Polyclonal Antibodies ResearchLysisContext (archaeology)Drug discoveryChemistryComputational biologyLigand binding assayLigand (biochemistry)Plasma protein bindingKinaseBiophysics

MeSH terms

Pharmaceutical PreparationsHot TemperatureHumansProtein BindingProteinsBlotting, WesternDrug Delivery SystemsMAP Kinase Signaling SystemMitogen-Activated Protein Kinase 14Protein StabilityDrug Discovery

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The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

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