reviewTop 1% cited
Denosumab and bisphosphonates: Different mechanisms of action and effects
Bone · 2010 · Vol. 48(4) · pp. 677–692
Bone health and treatmentsBone Metabolism and DiseasesBone and Joint DiseasesDenosumabOsteoclastRANKLBone resorptionBisphosphonateOsteoporosisMedicineBone Density Conservation AgentsOsteolysisBone remodeling
MeSH terms
DenosumabAnimalsAntibodies, MonoclonalClinical Trials as TopicDiphosphonatesDisease Models, AnimalHumansOsteoclastsOsteoporosisBone Density Conservation AgentsRANK LigandAntibodies, Monoclonal, Humanized
Funding
- Amgen
- GlaxoSmithKline
Citations
701
FWCI
14.39
field-weighted impact
References
187
Percentile
99%
vs. same field & year
Citations per year
Cited by
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Bisphosphonates: The first 40years
Bone · 2011 · 1,093 citations
References
Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density
Cell · 1997 · 5,099 citations
Suppressed Bone Turnover by Bisphosphonates Increases Microdamage Accumulation and Reduces Some Biomechanical Properties in Dog Rib
Journal of Bone and Mineral Research · 2000 · 695 citations
Osteocytes, mechanosensing and Wnt signaling
Bone · 2008 · 1,055 citations
Severely Suppressed Bone Turnover: A Potential Complication of Alendronate Therapy
The Journal of Clinical Endocrinology & Metabolism · 2005 · 1,422 citations
RANK is essential for osteoclast and lymph node development
Genes & Development · 1999 · 1,484 citations
Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation
Cell · 1998 · 5,439 citations
A Single-Dose Placebo-Controlled Study of AMG 162, a Fully Human Monoclonal Antibody to RANKL, in Postmenopausal Women
Journal of Bone and Mineral Research · 2004 · 762 citations
Comparison of the Effect of Denosumab and Alendronate on BMD and Biochemical Markers of Bone Turnover in Postmenopausal Women With Low Bone Mass: A Randomized, Blinded, Phase 3 Trial
Journal of Bone and Mineral Research · 2008 · 598 citations
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