articleTop 1% cited
The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen
Breast Cancer Research and Treatment · 2006 · Vol. 101(1) · pp. 113–121
Matthew P. Goetz✉(Mayo Clinic)Stacey K. Knox(Mayo Clinic)Vera J. Suman(Mayo Clinic)James M. Rae(Michigan Medicine)Stephanie L. Safgren(Mayo Clinic)Matthew M. Ames(Mayo Clinic)Daniel W. Visscher(Mayo Clinic)Carol Reynolds(Mayo Clinic)Fergus J. Couch(Mayo Clinic)Wilma L. Lingle(Mayo Clinic)Richard M. Weinshilboum(Mayo Clinic)Emily G. Barr Fritcher(Mayo Clinic)Andrea M. Nibbe(Mayo Clinic)Zeruesenay Desta(Indiana University Bloomington)Anne Nguyen(Indiana University Bloomington)David A. Flockhart(Indiana University Bloomington)Edith A. Perez(WinnMed)James N. Ingle(Mayo Clinic)
Estrogen and related hormone effectsPharmacogenetics and Drug MetabolismInflammatory mediators and NSAID effectsCYP2D6TamoxifenBreast cancerInternal medicineMedicinePharmacologyEndocrinologyCytochrome P450CancerEstrogen
MeSH terms
AdultAgedAged, 80 and overBreast NeoplasmsFemaleGenotypeHumansMiddle AgedNeoplasm Recurrence, LocalTamoxifenProportional Hazards ModelsTreatment OutcomeChemotherapy, AdjuvantAntineoplastic Agents, HormonalCytochrome P-450 CYP2D6
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References
The effect of selective serotonin re‐uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes.
British Journal of Clinical Pharmacology · 1992 · 469 citations
Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: Implication for optimization of breast cancer treatment
Clinical Pharmacology & Therapeutics · 2006 · 478 citations
Randomized Trial of Letrozole Following Tamoxifen as Extended Adjuvant Therapy in Receptor-Positive Breast Cancer: Updated Findings from NCIC CTG MA.17
JNCI Journal of the National Cancer Institute · 2005 · 1,117 citations
Pharmacological Characterization of 4-hydroxy-N-desmethyl Tamoxifen, a Novel Active Metabolite of Tamoxifen
Breast Cancer Research and Treatment · 2004 · 455 citations
Tamoxifen for the Prevention of Breast Cancer: Current Status of the National Surgical Adjuvant Breast and Bowel Project P-1 Study
JNCI Journal of the National Cancer Institute · 2005 · 1,331 citations
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