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Receptor binding profile of R 41 468, A novel antagonist at 5-HT2 receptors

Life Sciences · 1981 · Vol. 28(9) · pp. 1015–1022

J.E. Leysen✉(Janssen (Belgium))F. Awouters(Janssen (Belgium))Ludo Kennis(Janssen (Belgium))Pierre M. Laduron(Janssen (Belgium))J. VANDENBERK(Janssen (Belgium))Paul A. J. Janssen(Janssen (Belgium))

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Receptor Mechanisms and Signaling Neurotransmitter Receptor Influence on Behavior Pharmacological Effects and AssaysReceptorPhenoxybenzamineAntagonist5-HT2 receptor5-HT receptorChemistryReceptor antagonistCompetitive antagonistPharmacologyMechanism of action

MeSH terms

AnimalsBrainGuinea PigsKetanserinKineticsPiperidinesReceptors, Adrenergic, alphaReceptors, CholinergicReceptors, DopamineReceptors, SerotoninSerotonin AntagonistsRats

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844

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References

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Biochemical Pharmacology · 1973 · 12,855 citations

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