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pH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium

International Journal of Biological Macromolecules · 2010 · Vol. 46(5) · pp. 517–523
Shuibo HuaHaizhen MaXun LiHuixia YangAiqin Wang
Hydrogels: synthesis, properties, applicationsAdvanced Drug Delivery SystemsDrug Solubulity and Delivery SystemsSwellingVinyl alcoholDiclofenac SodiumFourier transform infrared spectroscopyEntrapmentDrug deliverySodiumSodium alginateChemical engineeringChemistry

MeSH terms

Spectroscopy, Fourier Transform InfraredHydrogel, Polyethylene Glycol DimethacrylateGlucuronic AcidAlginatesCalciumCross-Linking ReagentsDelayed-Action PreparationsDiclofenacFreezingHexuronic AcidsHydrogen-Ion ConcentrationMicroscopy, Electron, ScanningMicrospheresPolyvinyl AlcoholX-Ray Diffraction

Funding

  • Chinese Academy of Sciences
  • Bijzonder Onderzoeksfonds UGent
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