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AUTOLOGOUS FIBRIN-CULTURED LIMBAL STEM CELLS PERMANENTLY RESTORE THE CORNEAL SURFACE OF PATIENTS WITH TOTAL LIMBAL STEM CELL DEFICIENCY1

Transplantation · 2001 · Vol. 72(9) · pp. 1478–1485

Paolo Rama(Zero to Three)С. Бонини(Zero to Three)Alessandro Lambìase(Zero to Three)Osvaldo GolisanoPatrizia PaternaMichele De Luca✉(Istituto Dermopatico dell'Immacolata)Graziella Pellegrini

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Abstract

Preservation of limbal stem cells in culture gives new perspectives on the treatment of ocular disorders characterized by complete limbal stem cell deficiency. The multicenter nature of this study and the handiness and ease of long-distance transportation of the fibrin-cultured epithelial sheets suggest that this technology can now be widely applied.

Corneal Surgery and Treatments Ocular Surface and Contact Lens Corneal surgery and disordersLimbal stem cellFibrinStem cellMedicineCorneal epitheliumOphthalmologyCorneal DiseasesPathologyCorneaSurgery

MeSH terms

AdultAnimalsCells, CulturedCorneaEye BurnsFemaleFibrinHumansFunctional LateralityMaleMiddle AgedTransplantation, AutologousKeratinocytesCorneal Transplantation3T3 Cells

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506

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9.37

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Functional bioengineered corneal epithelial sheet grafts from corneal stem cells expanded ex vivo on a temperature-responsive cell culture surface