article Open AccessTop 1% cited
Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice
Gut · 2012 · Vol. 62(12) · pp. 1787–1794
Tiphaine Le Roy(Microbiologie de l’alimentation au service de la santé)Marta Llopis(Microbiologie de l’alimentation au service de la santé)Patricia Lepage(AgroParisTech)Aurélia Bruneau(AgroParisTech)Sylvie Rabot(AgroParisTech)Claudia BevilacquaPatrice MartinCatherine Philippe(Microbiologie de l’alimentation au service de la santé)Francine Walker(Sorbonne Paris Cité)André Bado(Université Paris Cité)Gabriel Perlemuter(Université Paris-Sud)Anne‐Marie Cassard(Inserm)Philippe Gérard✉(AgroParisTech)
Abstract
Differences in microbiota composition can determine response to a HFD in mice. These results further demonstrate that the gut microbiota contributes to the development of NAFLD independently of obesity.
Gut microbiota and healthLiver Disease Diagnosis and TreatmentDiet and metabolism studiesGut floraFatty liverBiologyInternal medicineLipogenesisSteatosisEndocrinologyMetabolic syndromeSteatohepatitisInflammation
MeSH terms
AnimalsBlood GlucoseDietary FatsFatty Acids, VolatileFatty LiverIntestinesLiverMaleMice, Inbred C57BLRNA, BacterialRNA, Ribosomal, 16STriglyceridesPolymerase Chain ReactionMiceMicrobiota
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971
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