articleTop 1% cited
Effects of Exenatide (Exendin-4) on Glycemic Control and Weight Over 30 Weeks in Metformin-Treated Patients With Type 2 Diabetes
Diabetes Care · 2005 · Vol. 28(5) · pp. 1092–1100
Ralph A. DeFronzo✉(The University of Texas Health Science Center at San Antonio)Robert E. Ratner(MedStar Health)Jenny Han(Amplyx Pharmaceuticals (United States))Dennis Dong Hwan Kim(Amplyx Pharmaceuticals (United States))Mark Fineman(Amplyx Pharmaceuticals (United States))Alain Baron(Amplyx Pharmaceuticals (United States))
Abstract
Exenatide was generally well tolerated and reduced HbA(1c) with no weight gain and no increased incidence of hypoglycemia in patients with type 2 diabetes failing to achieve glycemic control with metformin.
Diabetes Treatment and ManagementDiabetes Management and ResearchMetabolism, Diabetes, and CancerExenatideMedicineMetforminPlaceboGlycemicHypoglycemiaInternal medicineType 2 diabetesDiabetes mellitusPopulation
MeSH terms
ExenatideAdultAgedBlood GlucoseBody WeightDiabetes Mellitus, Type 2Drug Therapy, CombinationFemaleGlycated HemoglobinHumansHyperglycemiaHypoglycemic AgentsInsulinMaleMetformin
Funding
- Amylin Pharmaceuticals
- U.S. Food and Drug Administration
Citations
1,553
FWCI
73.08
field-weighted impact
References
37
Percentile
100%
vs. same field & year
Citations per year
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References
Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers
American Journal of Physiology-Endocrinology and Metabolism · 2001 · 467 citations
Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans
American Journal of Physiology-Endocrinology and Metabolism · 2004 · 608 citations
The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
Journal of Clinical Investigation · 1999 · 1,945 citations
Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in Type 2 (non-insulin-dependent) diabetic patients
Diabetologia · 1993 · 1,087 citations
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
The Lancet · 1998 · 19,985 citations
U.K. Prospective Diabetes Study 16: Overview of 6 Years' Therapy of Type II Diabetes: A Progressive Disease
Diabetes · 1995 · 1,917 citations
Applied Linear Statistical Models
Technometrics · 1992 · 9,961 citations
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