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Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

Nature Medicine · 2004 · Vol. 10(8) · pp. 858–864
Daniel J. CeradiniAnita R. KulkarniMatthew J. CallaghanOren M. TepperNicholas BastidasMark E. KleinmanJennifer M. CaplaRobert D. GalianoJamie P. LevineGeoffrey C. Gurtner
Cancer, Hypoxia, and MetabolismChemokine receptors and signalingAngiogenesis and VEGF in CancerProgenitor cellCell biologyHoming (biology)Stromal cellStromal cell-derived factor 1Stem cellBiologyCXCR4Endothelial progenitor cellEndothelial stem cell

MeSH terms

Analysis of VarianceAnimalsBone MarrowCell AdhesionCell MovementDisease Models, AnimalDNA-Binding ProteinsEnzyme-Linked Immunosorbent AssayGene Expression RegulationIschemiaMice, NudeNuclear ProteinsPrecipitin TestsStem CellsTranscription Factors

Funding

  • Sarnoff Cardiovascular Research Foundation
  • National Institutes of Health
  • National Institute of Biomedical Imaging and Bioengineering
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