article Open AccessTop 1% cited
Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition
BMC Cancer · 2014 · Vol. 14(1) · pp. 1–1
Gaofeng Xiong(Markey Cancer Center)Lei Deng(Markey Cancer Center)Jieqing Zhu(University of Kentucky)Piotr Rychahou(University of Kentucky)Ren Xu✉(University of Kentucky)
Abstract
These results suggest the critical role of P4HA2 in breast cancer progression and identify P4HA2 as a potential therapeutic target and biomarker for breast cancer progression.
Epigenetics and DNA MethylationBone and Dental Protein StudiesCancer, Hypoxia, and MetabolismBreast cancerMetastasisCancer researchGene silencingCancerTumor progressionMedicineSurgical oncologyInternal medicineBiology
MeSH terms
Collagen Type I, alpha 1 ChainAnimalsBreast NeoplasmsCollagenEnzyme InhibitorsFemaleHumansLung NeoplasmsNeoplasm InvasivenessPhenotypePrognosisProcollagen-Proline DioxygenaseRNA, MessengerTime FactorsTransfection
Funding
- American Heart Association
- National Institutes of Health
- National Center for Research Resources
- National Center for Advancing Translational Sciences
Citations
753
FWCI
31.89
field-weighted impact
References
57
Percentile
100%
vs. same field & year
Citations per year
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Nature · 2002 · 9,574 citations
The extracellular matrix: A dynamic niche in cancer progression
The Journal of Cell Biology · 2012 · 2,974 citations
Procollagen trafficking, processing and fibrillogenesis
Journal of Cell Science · 2005 · 775 citations
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