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Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population

AIDS · 2000 · Vol. 14(4) · pp. 357–366

David R. Bangsberg✉(University of California, San Francisco)Frederick Hecht(University of California, San Francisco)Edwin D. CharleboisAndrew Zolopa(Palo Alto University)Mark Holodniy(Stanford University)Lewis B. Sheiner(NGM Biopharmaceuticals (United States))Joshua D. Bamberger(San Francisco Department of Public Health)Margaret A. Chesney(San Francisco AIDS Foundation)Andrew R. Moss(Cancer Research And Biostatistics)

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Abstract

A substantial proportion of homeless and marginally housed individuals had good adherence to PI therapy. A strong relationship was found between independent methods of measuring adherence and concurrent viral suppression. PI resistance was more closely related to the failure to change RTI when starting a PI than to the level of adherence.

HIV/AIDS Research and Interventions HIV/AIDS drug development and treatment HIV Research and TreatmentViral loadMedicinePillProtease inhibitor (pharmacology)Internal medicinePopulationDrug resistanceHIV drug resistanceLentivirusCohort study

MeSH terms

AdultDrug Resistance, MicrobialDrug Therapy, CombinationFemaleGenotypeIll-Housed PersonsHumansMaleMedical IndigencyPatient ComplianceCohort StudiesHIV-1Multivariate AnalysisHIV Protease InhibitorsReverse Transcriptase Inhibitors

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