articleTop 1% cited
Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis
Annals of Neurology · 1981 · Vol. 10(2) · pp. 122–126
Peter J. Whitehouse✉(Johns Hopkins University)Donald L. Price(Johns Hopkins Medicine)Arthur W. Clark(Johns Hopkins University)Joseph T. Coyle(Johns Hopkins Medicine)Mahlon R. DeLong(Johns Hopkins University)
Abstract
The nucleus basalis of Meynert provides diffuse cholinergic input to the neocortex. When compared with an age- and sex-matched control, the nucleus basalis from a patient with Alzheimer disease demonstrated substantial reduction of neurons. Loss of this neuronal population may represent an anatomical correlate of the well-documented cholinergic derangement in Alzheimer disease.
Memory and Neural MechanismsCholinesterase and Neurodegenerative DiseasesNeuroscience and Neuropharmacology ResearchNucleus basalisNeocortexCholinergicNeuroscienceCholinergic neuronDiseaseAlzheimer's diseaseNucleusPopulationBiology
MeSH terms
AgedAlzheimer DiseaseBasal GangliaCell CountCholinergic FibersDementiaHumansMale
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References
THE ASCENDING CHOLINERGIC RETICULAR SYSTEM: NEOCORTICAL, OLFACTORY AND SUBCORTICAL PROJECTIONS
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