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Evidence for Antibody-Mediated Injury as a Major Determinant of Late Kidney Allograft Failure

Transplantation · 2010 · Vol. 90(1) · pp. 68–74

Robert S. Gaston✉(University of Alabama at Birmingham)J. Michael CeckaBert L Kasiske(Hennepin County Medical Center)Ann Fieberg(University of Minnesota)Robert Leduc(University of Minnesota)Fernando Cosio(Mayo Clinic in Arizona)Sita GourishankarJoseph P. Grande(Mayo Clinic)Philip F. HalloranLawrence G. HunsickerRoslyn B. Mannon(University of Alabama at Birmingham)David N. RushArthur J. Matas(University of Minnesota)

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Abstract

Evidence of antibody-mediated injury (DSA or C4d) is common (57%) in patients with new onset late kidney allograft dysfunction. The risk of subsequent graft failure is significantly worse in the presence of C4d+ staining.

Renal Transplantation Outcomes and Treatments Organ Transplantation Techniques and Outcomes Neurological Complications and SyndromesMedicineCreatinineNephrotoxicityCalcineurinKidneyRenal functionBiopsyUrologyGastroenterologyInternal medicine

MeSH terms

AdultBiopsyCreatinineEthnicityFemaleGraft SurvivalHistocompatibility TestingHLA AntigensHumansImmunity, CellularIsoantibodiesMaleMiddle AgedPeptide FragmentsRisk Factors

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480

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Cited by

Consensus Guidelines on the Testing and Clinical Management Issues Associated With HLA and Non-HLA Antibodies in Transplantation