article Open AccessTop 1% cited
PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress
Cell Death and Differentiation · 2012 · Vol. 19(11) · pp. 1880–1891
Tom Verfaillie✉(KU Leuven)Noemí Rubio(University of Liège)Abhishek D. Garg(KU Leuven)Geert Bultynck(VIB-KU Leuven Center for Cancer Biology)Rosario Rizzuto(National Research Council)J-P Decuypere(VIB-KU Leuven Center for Cancer Biology)Jacques Piette(University of Liège)Chris Linehan(Ollscoil na Gaillimhe – University of Galway)Sanjeev Gupta(Ollscoil na Gaillimhe – University of Galway)Afshin Samali(Ollscoil na Gaillimhe – University of Galway)Patrizia Agostinis(KU Leuven)
Endoplasmic Reticulum Stress and DiseaseAutophagy in Disease and TherapyRNA regulation and diseaseUnfolded protein responseEndoplasmic reticulumCell biologyMitochondrionApoptosisProgrammed cell deathEIF-2 kinaseThapsigarginReactive oxygen speciesBiology
MeSH terms
AnimalsCell LineHumansLightMitochondriaApoptosisReactive Oxygen SpeciesThapsigargineIF-2 KinaseCalcium SignalingHCT116 CellsMitochondrial MembranesMiceTranscription Factor CHOPUnfolded Protein Response
Funding
- Cancer Research Institute
- Fonds De La Recherche Scientifique - FNRS
- KU Leuven
- National Institutes of Health
- Abramson Family Cancer Research Institute
Citations
820
FWCI
16.05
field-weighted impact
References
40
Percentile
100%
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Citations per year
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References
Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response
Molecular Cell · 2000 · 1,997 citations
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
Nature Cell Biology · 2011 · 2,594 citations
Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1
Developmental Cell · 2007 · 1,023 citations
Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival
Molecular and Cellular Biology · 2003 · 1,204 citations
An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress
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Photodynamic therapy of cancer: An update
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