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Adjuvant trastuzumab in the treatment of her-2-positive early breast cancer: a meta-analysis of published randomized trials
BMC Cancer · 2007 · Vol. 7(1) · pp. 153–153
Gustavo Arruda Viani✉(Faculdade de Medicina de Marília)Sergio Afonso(Faculdade de Medicina de Marília)Eduardo Jose Stefano(Faculdade de Medicina de Marília)Lígia Issa De Fendi(Faculdade de Medicina de Marília)Francisco V Soares(Faculdade de Medicina de Marília)
Abstract
The results from this meta-analysis are sufficiently compelling to consider 1 year of adjuvant trastuzumab treatment for women with HER-2-positive EBC based on the risk: benefit ratio demonstrated in these studies. Adequate assessment of HER-2/neu status is critical, and careful cardiac monitoring is warranted because of cardiac toxicity. Clinical trials should be designed to answer unsolved questions.
HER2/EGFR in Cancer ResearchBreast Cancer Treatment StudiesAngiogenesis and VEGF in CancerTrastuzumabMedicineSurgical oncologyBreast cancerOncologyAdjuvantRandomized controlled trialMeta-analysisInternal medicineCancer
MeSH terms
TrastuzumabAntibodies, MonoclonalAntineoplastic AgentsBrain NeoplasmsBreast NeoplasmsFemaleGene AmplificationHeart DiseasesHumansRecurrenceGlobal HealthComorbidityCausalityIncidenceOdds Ratio
Citations
376
FWCI
12.61
field-weighted impact
References
33
Percentile
99%
vs. same field & year
Citations per year
References
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Journal of Clinical Oncology · 2002 · 2,949 citations
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Science · 1987 · 11,680 citations
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