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Quinolines as potent 5-lipoxygenase inhibitors: Synthesis and biological profile of L-746,530
Bioorganic & Medicinal Chemistry Letters · 1998 · Vol. 8(10) · pp. 1255–1260
Daniel Dubé✉(Merck & Co., Inc., Rahway, NJ, USA (United States))Marc Blouin(Merck Canada Inc. (Canada))Christine Brideau(Merck Canada Inc. (Canada))Chi‐Chung Chan(Merck Canada Inc. (Canada))Sylvie Desmarais(Merck Canada Inc. (Canada))Diane Ethier(Merck Canada Inc. (Canada))Jean‐Pierre Falgueyret(Merck Canada Inc. (Canada))Richard W. Friesen(Merck Canada Inc. (Canada))M. Fusco Girard(Merck Canada Inc. (Canada))Yves Girard(Merck Canada Inc. (Canada))Jocelyne Guay(Merck Canada Inc. (Canada))Denis Riendeau(Merck Canada Inc. (Canada))Philip Tagari(Merck Canada Inc. (Canada))Robert N. Young(Merck Canada Inc. (Canada))
Asthma and respiratory diseasesPediatric health and respiratory diseasesRespiratory and Cough-Related ResearchChemistryArachidonate 5-lipoxygenaseIn vivoQuinolineEnzymeIn vitroChemical synthesisStereochemistryPotencyEnzyme inhibitor
MeSH terms
Bridged Bicyclo CompoundsHumansLeukotriene B4Models, MolecularNaphthalenesNeutrophilsQuinolinesRecombinant ProteinsMolecular StructureLipoxygenase Inhibitors
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271
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0.71
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19
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68%
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References
Nickel-Phosphine Complex-Catalyzed Grignard Coupling. I. Cross-Coupling of Alkyl, Aryl, and Alkenyl Grignard Reagents with Aryl and Alkenyl Halides: General Scope and Limitations
Bulletin of the Chemical Society of Japan · 1976 · 586 citations
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