articleTop 1% cited
Evidence That Hepatitis C Virus Resistance to Interferon Is Mediated through Repression of the PKR Protein Kinase by the Nonstructural 5A Protein
Virology · 1997 · Vol. 230(2) · pp. 217–227
Michael Gale(University of Washington)Marcus J. Korth(University of Washington)Norina Tang(University of Washington)Seng-Lai Tan(University of Washington)Deborah Hopkins(University of Washington)Thomas Dever(National Institutes of Health)Stephen J. Polyak(University of Washington)David R. Gretch(University of Washington)Michael G. Katze✉(University of Washington)
RNA regulation and diseaseinterferon and immune responsesHepatitis C virus researchNS5AProtein kinase RBiologyInterferonVirologyHepatitis C virusProtein kinase AVirusEIF-2 kinaseHepacivirus
MeSH terms
Antiviral AgentsBinding SitesCatalysisDrug Resistance, MicrobialHumansInterferon Type IRecombinant Fusion ProteinsRepressor ProteinsRNA-Dependent RNA PolymeraseHepacivirusProtein Serine-Threonine KinasesViral Nonstructural ProteinseIF-2 Kinase
Citations
809
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References
66
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Survey of major genotypes and subtypes of hepatitis C virus using RFLP of sequences amplified from the 5' non-coding region
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Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Analytical Biochemistry · 1987 · 46,850 citations
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