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Structure–activity relationship study of novel necroptosis inhibitors

Bioorganic & Medicinal Chemistry Letters · 2005 · Vol. 15(22) · pp. 5039–5044

Xin Teng(Harvard University)Alexei Degterev(Harvard University)Prakash G. Jagtap(Brigham and Women's Hospital)Xuechao Xing(Harvard University)Sung‐Woon Choi(Harvard University)Régine Denu(Brigham and Women's Hospital)Junying Yuan(Harvard University)Gregory D. Cuny✉(Brigham and Women's Hospital)

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Cell death mechanisms and regulation Neuroscience and Neuropharmacology Research Mass Spectrometry Techniques and ApplicationsNecroptosisChemistryFADDJurkat cellsStereochemistryIndole testProgrammed cell deathInhibitory postsynaptic potentialStructure–activity relationshipApoptosis

MeSH terms

AnimalsHumansHydantoinsInjections, IntravenousMaleMethylationNecrosisStructure-Activity RelationshipSulfhydryl CompoundsTumor Necrosis Factor-alphaMolecular StructureCell DeathJurkat CellsMice

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