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Increased Local Recurrence and Reduced Survival From Colorectal Cancer Following Anastomotic Leak

Annals of Surgery · 2011 · Vol. 253(5) · pp. 890–899

Alexander Mirnezami✉(University of Southampton)Reza Mirnezami(Hammersmith Hospital)Kandiah Chandrakumaran(Basingstoke and North Hampshire Hospital)K Sasapu(Leeds General Infirmary)P. M. Sagar(Leeds General Infirmary)P J Finan(Leeds General Infirmary)

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Abstract

AL has a negative prognostic impact on local recurrence after restorative resection of rectal cancer. A significant association between colorectal AL and reduced long-term cancer specific survival was also noted. No association between AL and distant recurrence was found.

Colorectal Cancer Surgical Treatments Colorectal and Anal Carcinomas Colorectal Cancer Screening and DetectionMedicineColorectal cancerMeta-analysisAnastomosisFunnel plotPublication biasOdds ratioInternal medicineStudy heterogeneitySurgery

MeSH terms

AdultAge FactorsAgedAnastomosis, SurgicalColectomyFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm Recurrence, LocalSex FactorsTime FactorsColorectal NeoplasmsIncidence

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