articleTop 1% cited

Activation of the interferon system by short-interfering RNAs

Nature Cell Biology · 2003 · Vol. 5(9) · pp. 834–839

Carol A. Sledz(Case Western Reserve University)Michelle Holko(Case Western Reserve University)Michael J. de Veer(Cleveland Clinic Lerner College of Medicine)Robert H. Silverman(Case Western Reserve University)Bryan Williams✉(Cleveland Clinic)

View via DOI Publisher page

RNA Interference and Gene Delivery interferon and immune responses RNA regulation and diseaseRNA interferenceSmall interfering RNARNA silencingGene silencingInterferonCell biologyBiologyTrans-acting siRNADownregulation and upregulationTransfection

MeSH terms

AnimalsCells, CulturedDrosophila melanogasterEukaryotic CellsInterferon InducersInterferonsProtein-Tyrosine KinasesRNA, Double-StrandedRNA, ViralUp-RegulationGene Expression Regulation, ViraleIF-2 KinaseGene SilencingRNA InterferenceRNA, Small Interfering

Funding

National Institutes of Health

Citations

1,398

FWCI

61.17

field-weighted impact

References

Percentile

100%

vs. same field & year

Citations per year

Cited by

Noncoding RNA therapeutics — challenges and potential solutions

Nature Reviews Drug Discovery · 2021 · 1,517 citations

References

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Nature · 2001 · 9,337 citations

HOW CELLS RESPOND TO INTERFERONS

Annual Review of Biochemistry · 1998 · 3,942 citations

Citation Network

How this paper connects to the literature. Drag to explore, click any node to open that paper.