articleTop 10% cited
Catalytic Enantioselective Alkynylation of Prochiral sp<sup>3</sup> C−H Bonds Adjacent to a Nitrogen Atom
Organic Letters · 2004 · Vol. 6(26) · pp. 4997–4999
Zhiping Li✉(McGill University)Chao‐Jun Li(McGill University)
Abstract
[reaction: see text] The construction of chiral carbon centers via the first catalytic asymmetric alkynylation of prochiral CH2 groups was developed by using a copper-catalyzed double activation of sp3 and sp C-H bonds. Optically active 1-alkynylated tetrahydroisoquinolines were obtained by this method.
Catalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and CatalysisAlkynylationChemistryEnantioselective synthesisCatalysisNitrogen atomNitrogenAsymmetric carbonCopperAtom (system on chip)Optically active
MeSH terms
AcetyleneAlkynesCatalysisCopperIsoquinolinesNitrogenStereoisomerismMolecular Structure
Funding
- Natural Sciences and Engineering Research Council of Canada
Citations
364
FWCI
5.93
field-weighted impact
References
15
Percentile
97%
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Citations per year
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Catalytic Enantioselective Alkynylation of Prochiral sp<sup>3</sup> C−H Bonds Adjacent to a Nitrogen Atom
Organic Letters · 2004 · 364 citations
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