reviewTop 1% cited
Nrf2 the rescue: Effects of the antioxidative/electrophilic response on the liver
Toxicology and Applied Pharmacology · 2010 · Vol. 244(1) · pp. 57–65
Curtis D. Klaassen✉(University of Kansas Medical Center)Scott A. Reisman(University of Kansas Medical Center)
Genomics, phytochemicals, and oxidative stressGlutathione Transferases and PolymorphismsDrug-Induced Hepatotoxicity and ProtectionXenobioticGlutathioneOxidative stressChemistryDrug metabolismBiochemistryEffluxToxicokineticsPharmacologyBiology
MeSH terms
AnimalsAntioxidantsGene Expression RegulationHumansLiverInactivation, MetabolicSignal TransductionOxidative StressCytoprotectionMultidrug Resistance-Associated ProteinsATP-Binding Cassette, Sub-Family C ProteinsNF-E2-Related Factor 2MiceChemical and Drug Induced Liver Injury
Funding
- National Institutes of Health
Citations
385
FWCI
13.66
field-weighted impact
References
104
Percentile
99%
vs. same field & year
Citations per year
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References
An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements
Biochemical and Biophysical Research Communications · 1997 · 3,915 citations
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
Genes & Development · 1999 · 3,543 citations
Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2
Molecular and Cellular Biology · 2004 · 2,165 citations
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