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Interpreting the significance of changes in health-related quality-of-life scores.
Journal of Clinical Oncology · 1998 · Vol. 16(1) · pp. 139–144
David Osoba✉(BC Cancer Agency)George Rodrigues(University of British Columbia)James D. Myles(University of British Columbia)Benny ZeeJoseph L. Pater(University of British Columbia)
Abstract
The significance of changes in QLQ-C30 scores can be interpreted in terms of small, moderate, or large changes in quality of life as reported by patients in the SSQ. The magnitude of these changes also can be used to calculate the sample sizes required to detect a specified change in clinical trials.
Cancer survivorship and careChildhood Cancer Survivors' Quality of LifeFamily Support in IllnessMedicineQuality of life (healthcare)ConcordanceClinical significanceStatistical significanceHealth related quality of lifeCancerInternal medicineDisease
MeSH terms
Breast NeoplasmsHumansInterpersonal RelationsLung NeoplasmsMiddle AgedQuality of LifeSurveys and QuestionnairesSeverity of Illness IndexCarcinoma, Small Cell
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References
Determining a minimal important change in a disease-specific quality of life questionnaire
Journal of Clinical Epidemiology · 1994 · 1,824 citations
The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-Life Instrument for Use in International Clinical Trials in Oncology
JNCI Journal of the National Cancer Institute · 1993 · 15,705 citations
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